Join us for an insightful webinar that explores the world of nucleotide excision repair (NER), a key mechanism in DNA repair, and its critical implications for cancer treatment.
In this session, hosted by DNA repair expert Dr. Ingrid Tessmer, Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, we dive deep into the role of alkyltransferase-like proteins (ATLs) and their role in NER. Despite their inherent catalytic inactivity, ATLs play a remarkable role in targeting alkyl lesions for repair by the NER system. Through a combination of single-molecule and ensemble methodologies, a detailed view of the recruitment process of UvrA – the initiating enzyme of prokaryotic NER – to an alkyl lesion by ATL has been observed for the first time.
Moreover, we delve into the mechanisms of lesion recognition by ATL, and illustrate the dynamic DNA lesion search undertaken by highly active ATL and ATL-UvrA complexes.
Don’t miss this opportunity to broaden your understanding of DNA repair and its potential role in revolutionizing cancer treatment strategies.
Key learning points:
- Introduction to mechanisms of alkyltransferase based DNA repair
- What is the role of alkyltransferase-like proteins (ATLs) in recruiting NER repair proteins like UvrA?
- How do ATL-UvrA complexes dynamically search DNA for lesions?
- How is understanding the AGT and ATL lesion search process opening up new DNA-repair based cancer treatment strategies?
