Learn how our latest single-molecule tool, the C-Trap Edge, is used in leading research to identify potential drug targets for hereditary neuro-developmental disorders.
Following a short introduction to dynamic single-molecule analysis and the most popular applications, senior application scientist Dr. Trey Simpson dives right into the exciting innovations of the C-Trap Edge that further expand experimental possibilities.
In the second part, Professor Arne Gennerich from the Albert Einstein College of Medicine explains how the unique capabilities of the C-Trap Edge enable him to investigate cytoskeletal motor protein function and dynamics, and their role in developmental diseases.
The motor protein KIF1A from the kinesin family of microtubule motor proteins is an important player in intracellular transport and is essential for neuronal development. Severe neuro-developmental disorders have been ascribed to mutations in related genes.
Quantifying the impact of these mutations on the function and dynamics of KIF1A is key for the development of effective therapeutics against this currently incurable disease, which is one of the major goals of Prof. Gennerich’s research.
Watch the webinar to hear about his findings!
